Juan Carlos de la Torre Selected Research

Infections

2/2024	Activation of protein kinase receptor (PKR) plays a pro-viral role in mammarenavirus-infected cells.
1/2024	Plasmid-Based Lassa Virus Reverse Genetics.
12/2023	Activation of Protein Kinase R (PKR) Plays a Pro-Viral Role in Mammarenavirus Infected Cells.
4/2023	Antivirals against monkeypox infections.
1/2023	Identification of In Vitro Inhibitors of Monkeypox Replication.
1/2022	Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host-directed antivirals.
7/2021	A SARS-CoV-2 nucleocapsid protein TR-FRET assay amenable to high-throughput screening.
1/2021	Lassa Virus Vaccine Candidate ML29 Generates Truncated Viral RNAs Which Contribute to Interfering Activity and Attenuation.
1/2020	Identification of Inhibitors of ZIKV Replication.
1/2020	High crossreactivity of human T cell responses between Lassa virus lineages.

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Juan Carlos de la Torre Research Topics

Disease

30	Infections 02/2024 - 03/2003
12	Virus Diseases (Viral Diseases) 10/2021 - 12/2004
10	Arenaviridae Infections 01/2018 - 03/2004
7	Lassa Fever (Fever, Lassa) 11/2022 - 10/2004
7	Persistent Infection 10/2016 - 06/2002
5	Vesicular Stomatitis 11/2022 - 06/2003
5	COVID-19 10/2021 - 01/2020
4	Fever (Fevers) 01/2020 - 06/2006
2	Smallpox (Variola) 04/2023 - 01/2023
2	Poxviridae Infections 04/2023 - 01/2023
2	Inflammation (Inflammations) 01/2018 - 01/2016
1	Mpox (monkeypox) 04/2023
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2021
1	Pneumonia (Pneumonitis) 01/2021
1	American Hemorrhagic Fever (Bolivian Hemorrhagic Fever) 01/2020
1	Herpesviridae Infections (Herpesvirus Infection) 01/2020
1	Human Influenza (Influenza) 01/2020
1	Zika Virus Infection 01/2020
1	Severe Acute Respiratory Syndrome 01/2020
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2019
1	Multiple Sclerosis 01/2019
1	Systemic Scleroderma (Systemic Sclerosis) 01/2018
1	Alzheimer Disease (Alzheimer's Disease) 01/2018
1	Rheumatoid Arthritis 01/2018
1	Splenomegaly 01/2018
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2017
1	Coinfection 11/2015
1	Neoplasms (Cancer) 02/2015
1	Nervous System Diseases (Neurological Disorders) 08/2013
1	Disease Progression 04/2013
1	Viral Meningitis 08/2011

Drug/Important Bio-Agent (IBA)

21	VaccinesIBA 01/2024 - 10/2004
18	Antiviral Agents (Antivirals)IBA 12/2023 - 03/2003
10	Ribavirin (Virazole)FDA LinkGeneric 01/2024 - 12/2008
9	Proteins (Proteins, Gene)FDA Link 10/2021 - 06/2003
7	Attenuated VaccinesIBA 01/2020 - 06/2006
7	Interferon Type IIBA 01/2018 - 11/2010
5	RNA (Ribonucleic Acid)IBA 12/2023 - 03/2003
5	AntigensIBA 11/2022 - 12/2004
5	InterferonsIBA 01/2018 - 01/2006
4	NucleoproteinsIBA 02/2024 - 08/2012
4	Glycoproteins (Glycoprotein)IBA 01/2021 - 06/2003
2	Exonucleases (3' 5' Exonuclease)IBA 02/2024 - 12/2023
2	tecovirimatIBA 04/2023 - 01/2023
2	brincidofovirIBA 04/2023 - 01/2023
2	AntibodiesIBA 10/2021 - 10/2016
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 09/2006
2	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 01/2020 - 11/2015
2	CytokinesIBA 01/2018 - 01/2015
2	Neutralizing AntibodiesIBA 10/2016 - 10/2004
2	Interleukin-10 (Interleukin 10)IBA 01/2016 - 08/2011
2	Peptide Hydrolases (Proteases)FDA Link 02/2011 - 12/2004
1	Protein Kinases (Protein Kinase)IBA 12/2023
1	Mycophenolic Acid (Cellcept)FDA LinkGeneric 04/2023
1	narasinIBA 04/2023
1	buparvaquoneIBA 04/2023
1	brequinarIBA 04/2023
1	AVN 944IBA 04/2023
1	TAK-165IBA 04/2023
1	ValinomycinIBA 04/2023
1	Antimycin AIBA 04/2023
1	RotenoneIBA 04/2023
1	Monensin (Coban)IBA 04/2023
1	Small Interfering RNA (siRNA)IBA 01/2022
1	CC-90009IBA 01/2022
1	remdesivirIBA 07/2021
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	3,5-diisopropylsalicylic acid (DIPS)IBA 01/2021
1	Metformin (Glucophage)FDA LinkGeneric 01/2021
1	InflammasomesIBA 01/2021
1	enhanced green fluorescent proteinIBA 01/2020
1	Codon (Codons)IBA 01/2020
1	Dimethyl FumarateIBA 01/2019
1	Phospholipases (Phospholipase)IBA 01/2018
1	Nucleic AcidsIBA 01/2018
1	EnzymesIBA 01/2018
1	2- (4- (5- (3,4- diethoxyphenyl)- 1,2,4- oxadiazol- 3- yl)- 2,3- dihydro- 1H- inden- 1- yl amino)ethanolIBA 01/2017
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2016
1	CalciumIBA 10/2016
1	PerforinIBA 10/2016
1	EpitopesIBA 11/2015
1	Antigen-Antibody Complex (Immune Complex)IBA 02/2015
1	ChemokinesIBA 01/2015
1	pyrimidineIBA 01/2014
1	Volatile Fatty AcidsIBA 08/2013
1	Valproic Acid (Depakote)FDA LinkGeneric 08/2013
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 08/2012
1	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 08/2012
1	PF-429242IBA 02/2012
1	Messenger RNA (mRNA)IBA 01/2012
1	Fluorouracil (Carac)FDA LinkGeneric 01/2012
1	Green Fluorescent ProteinsIBA 08/2011
1	Monoclonal AntibodiesIBA 08/2011
1	Purine NucleosidesIBA 07/2011
1	Alanine (L-Alanine)FDA Link 04/2011
1	RibonucleoproteinsIBA 04/2011
1	site 1 membrane-bound transcription factor peptidaseIBA 03/2011

Therapy/Procedure

10	Therapeutics 07/2020 - 02/2004
8	Off-Label Use 01/2024 - 07/2011
4	Drug Therapy (Chemotherapy) 01/2024 - 01/2016